MyBioSource.com's Cdk4 (C22) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunoprecipitation, and Western Blot. The Cdk4 (C22) Antibody was generated using CDK4, CMM3, and cyclin dependent kinase 4 as the antigen and it reacts with Human, Mouse, Rat, and C. elegans/Worm.
Description
Cyclin dependent kinases are key regulators of the progression of the cell cycle. Early in the cell cycle Cdk2. Cdk4. Cdk6 and their associated cyclins regulate the G1 to S phase transition (1. 2). Cdk2 plays a key role in the G1/S and S/G2 transitions through its associations with cyclin D1. cyclin D2. cyclin D3. cyclin E and cyclin A. Cdk4 also forms complexes with the D type cyclins. and is thought to regulate cell growth through the G1 phase of the cell cycle (3-6). The late stages of the cell cycle are regulated by another cyclin dependent kinase. Cdc2 p34. This kinase exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34-cyclin B complex that is required for the G2 to M phase transition (7.8).